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Nurse Teachings on Contraindications for Alpha-1 Adrenoceptor Antagonist Use

Patient/caregiver was educated on contraindications for Alpha-1 adrenoceptor antagonist use as follows:

  1. Alpha-1 adrenoceptor antagonists are contraindicated in individuals with abnormally high heart rates. So, if your heart rate is being abnormally high (consistently more than 100), with the use of these medications, report this to your physician immediately.
  2. Alpha-1 adrenoceptor antagonists are contraindicated in individuals with abnormally low blood pressures. Use of these medications in these individuals can result in extremely low blood pressure with reduced flow to vital organs, resulting in compromised function of these organs. So, if your blood pressures are being consistently low, with the use of these medications, report this to your physician.
  3. Alpha-1 adrenoceptor antagonists are mainly metabolized in the liver and for the most part excreted in bile with minor share excreted in the urine. If liver and kidney functions are deficient, the metabolism and excretion of these medications can suffer. This can lead to increased blood levels of the medication and metabolites for longer periods of time, resulting in toxicity and severe side effects. So, these medications should be used with caution in individuals with hepatic, biliary, and renal dysfunction.

 

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